Pyrimidine nucleotides -Explain Biosynthesis

[Sddanish]

Please explain in simpler words the biosynthesis of pyrimidine nucleotides.

[Madhav07]

You can get a short trick for this in jambulkar sir’s notes .!

[Aadish]

Pyrimidine nucleotide biosynthesis:

1. Starts with simple molecules (bicarbonate, glutamine, aspartate)
2. Forms orotic acid, then OMP, UMP, and other pyrimidines (CMP, TMP)
3. Key enzymes: carbamoyl phosphate synthetase II, dihydroorotate dehydrogenase
4. Pathway is regulated for balanced DNA/RNA synthesis

Essential for DNA and RNA production!

[Moksha_s]

Nice explanation @Aadish

[Bhavini]