What’s a recent development in your field or industry that excites you?
I have always been excited about CRISPR Gene Editing since my Master’s after watching the documentaries Unnatural Selection and Human Nature (highly recommended). I also chose it as my summer review project the next year. Jennifer Doudna was such huge inspiration… and I was so happy when she received the 2020 Nobel Prize in Chemistry, along with Emmanuelle Charpentier. So, I always look out for this space.
CRISPR-Based In Vivo Gene Editing (CRISPR 3.0)
CRISPR gene-editing technology has reached a major milestone: in vivo (inside the body) therapeutic applications.
In 2024, researchers demonstrated precise, permanent edits to faulty genes directly within human tissues, marking a huge leap from previous ex vivo methods (where cells are edited outside the body and then reintroduced).
Intellia Therapeutics and Editas Medicine reported successful early trials targeting genetic liver and blood disorders using lipid nanoparticle delivery systems. This opens the door to one-time cures for hereditary diseases like sickle cell anemia, ATTR amyloidosis, and certain eye disorders.
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Developing methods for teeth to regrow
Researchers have identified a gene called USAG-1 that suppresses tooth development. By targeting this gene with antibodies, they have successfully stimulated tooth regrowth in animal models.
Clinical trials have begun in humans using a drug that neutralizes the USAG-1 protein, with the goal of having it available for general use by 2030.
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This is fascinating! If successful, it will actually revitalize the Dentistry.
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A new era started when we heard “new cancer vaccination” in medical science!!!
It was a historical leap…
The new NHS Cancer Vaccine Launch Pad (CVLP) is a platform that will speed up access to a tailored cancer vaccine clinical trial for people who have been diagnosed with cancer.
10,000 cancer patient will be able to receive this vaccine according to National health science, UK by the year 2030, that is already under clinical trial phase.
This will surely bridge the gap between Gardasil that prevents HPV cervical cancer and other cancers.
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Why is this exciting?
One-time treatment: Instead of taking medicines for life, some inherited diseases might be cured with a single gene-editing procedure.
Hard-to-treat diseases: Diseases like sickle cell anemia (a blood disorder), ATTR amyloidosis (a liver-related genetic condition), and certain eye disorders now have hope for long-term or permanent cures.
Companies involved: Companies like Intellia Therapeutics and Editas Medicine are leading this work and have shown early success in human trials
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