Why are women more prone to autoimmune diseases compared to men ?

MBBS
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Its a fact that 80% autoimmune diseases occur in women. But what is the reason behind it? Is it genetics or hormones or some other reason ?

Here is what the researchers think -

  1. Due to X chromosome : immune related genes are present more in X chromosome and having two X chromosomes, there are more chances of inactivation or mosaicism of genes.
  2. The remaining fetal cells in the mothers body even after years can contribute to autoimmune risks.
  3. Estrogen makes immunity stronger which is good for making antibodies against infection but sometimes it makes the body attacks its own cells by mistake
  4. Stress and lifestyle can also play a role overtime
    Have you ever come across this in your clinical rotations or textbooks?

and if you are curious about how daily habits affect autoimmune diseases check out this post too

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Yes. Women are more prone towards the autoimmune diseases. RA is the most common condition we have encountered in our postings, that’s too in women mostly.

The reasons you have explained can be the potential causes of it.

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Wow that was something new

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Hygiene hypothesis being one of them as well

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Interesting fact, if it’s in our hands to prevent the immune disorders it’s an advantage. We can adopt the lifestyle changes required for ti.

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Good informationđź‘Ť.

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Interesting.

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