Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation leading to synovial proliferation and destruction of articular cartilage of joints.
Pathophysiology
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Prostaglandins β Responsible for pain and swelling of joints
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Cytokines β Responsible for progressive joint damage and inflammation
Treatment of Rheumatoid Arthritis
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NSAIDs - aspirin, ibuprofen, diclofenac
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Non-Biological DMARDs (Immunosuppressant ) - sulfasalzine, methotrexate
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Biological Agents -
TNF-Ξ± antagonist β Etanercept
IL-1 antagonist.
- Glucocorticoids - Prednisolone
Goals of Drug Therapy in Rheumatoid Arthritis
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Prevent articular cartilage damage and bony erosion
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Reduce pain, swelling, and joint stiffness
3)Preserve joint function and prevent deformity
Supportive Management
Regular physiotherapy and joint exercises
Weight management
Balanced anti-inflammatory diet
Patient education and medication adherence
Early diagnosis and timely treatment
Conclusion
Rheumatoid arthritis is a systemic autoimmune disorder requiring early intervention and long-term management. Combination therapy using DMARDs, biologics, glucocorticoids, and lifestyle modification helps reduce inflammation, prevent irreversible joint damage, and improve the patientβs quality of life.
MBH/PS
