Safest corticosteroid

A 32 year old pregnant women presents with an acute exacerbation of asthma. Which of the following oral corticosteroid is considered the safest option and why??

  • prednisolone
  • Dexamethasone
  • Betamethasone
  • Prednisone

Prednisolone is considered the safest oral corticosteroid during pregnancy because it is inactivated by the placenta, minimizing fetal exposure. In contrast, dexamethasone and betamethasone cross the placenta more readily, making them preferred only when fetal lung maturity is the goal, not for maternal asthma.

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I’ll go with prednisolone as it has a lower risk in her pregnancy.

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Prednisolone

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That’s a good and concise piece of information while comparing the one medicine to other. Simple description yet informative.

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prednisolone