Stevens-Johnson Syndrome is some time triggered by the Phenytoin.
What is SJS?
It is a rare mucocutaneous hypersensitivity reaction characterized by the epidermal necrosis,painful oral ulcers, erythematous maculopapular rashes and systemic symptoms such as fever and malaise.
Clinical Case Study
The patients had the complaints of fever,painful oral lesions,dysphagia and spreading rash over abdomen and chest his laboratory findings indicate that poorly controlled diabetes and elevated inflammatory markers by investigating this patient had an seizure for the management Phenytoin is administered after the four weeks of administration patient developed with an those mentioned symptoms.
Why phenytoin induce SJS
Because it is due to the immune- mediated T Cell activation leading to widespread keratinocyte apoptosis.
Is they take any step to control this
Yes,The Phenytoin drug was replaced with Levetiracetam it is a non-aromatic antiepileptic with low risk of hypersensitivity
https://pmc.ncbi.nlm.nih.gov/articles/PMC12257028/
Did you know about this ?
MBH/PS