Important question of pharmacology!!

General
1

which drug is bacteriostatic drug among first line ANTI TB drug therapy ??

can you give some side effects of the same ??

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2

Ethambutol because it inhibits cell wall synthesis (arabinogalactan synthesis) but doesn’t kill the bacteria directly — it prevents multiplication, making it bacteriostatic. S/E- Optic neuritis, peripheral neuropathy.

3

Ethambutol is considered as a known bacteriostatic agent (inhibits bacterial growth).
SEs: visual disturbances, optic neuritis, rashes, hyperuricemia, GI upset.

4

Side effects of Ethambutol:

  • Optic neuritis (most important) — causes decreased visual acuity, red-green color blindness
  • Peripheral neuropathy (rare
  • Rash
  • Joint pain
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6

Ethambutol is the bacteriostatic drug among the first-line anti-TB medications.

Its common side effects include optic neuritis, color vision disturbances, and gastrointestinal issues like nausea and vomiting.

Regular monitoring is necessary to catch any potential side effects early.

7

Ethambutol - Inhibits the enzyme arabinosyl transferase thus inhibit incorporation of mycolic acid to the cell wall
ADR-

  • Visual disturbance
  • Color blindness (basically for red and green color)
  • Optic neuritis with blurred vision
8

Drug is Ethambutol.
Side effects includes:
-Optic neuropathy/Optic neuritis/Retrobulbar
neuritis.
-Decreased visual acuity.
-Scotoma.
-Color blindness.
-Visual field defect.
-Peripheral neuropathy.
-Hepatotoxicity.
-Numbness and tingling of extremities due to peripheral neuritis.
-Mental confusion & Disorientation.
-Psychosis.

9

Ethambutol

10

Ethambutol
S/e - optic neuritis, allergic reaction, rash, etc

11

Ethambutol
A/e: Vision loss, difficult breathing, hallucinations.

12

Among first-line TB drugs, Ethambutol is bacteriostatic, meaning it stops the bacteria from growing. A key side effect is optic neuritis, which can cause vision problems, including difficulty seeing colors (especially red-green) or even vision loss.
Regular eye check-ups are super important with this one.

13

Ethambutol. I think most ones here are writing vision loss as the ADRs, but one thing I wanted to clarify is that Ethambutol’s vision-related toxicity is totally dose-dependent and typically reversible if detected early. And one aspect of Ethambutol that has always fascinated me is its historical use as a SOLO treatment for patients with chronic, drug-resistant tuberculosis (TB) who had no other options. Remarkably, even in these desperate cases, Ethambutol was able to convert cultures to negative in up to 50% of patients.

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14

Ethambutol

it can cause Optic neuritis, rash, joint pain