A 48 year old man presents with abdominal pain and watery diarrhea. Labs show a fasting serum gastrin of 800 pg/ml ( normal < 100 pg/ml). Secretin stimulation increases gastrin levels. What is the most likely diagnosis?
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Some Gastrin secreting tumor comes to my mind.
gastrinoma (most likely non-MEN1 related)
can be Zollinger-Ellison syndrome
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This is most likely Zollinger-Ellison Syndrome, where a tumor makes too much gastrin, causing high acid levels that lead to stomach pain and diarrhea. The secretin test helps confirm it because gastrin levels go up even more.
The most likely diagnosis is Zollinger-Ellison Syndrome (ZES) due to a gastrinoma, supported by elevated fasting serum gastrin and positive secretin stimulation test.