Why Clinical Trials Often Fail Real Patients

General
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Mostly all the medicines are tested under perfect conditions on carefully selected participants. Real patients are not even close to perfect. Older adults, women, and people with multiple illnesses who are susceptible to most of the common illness are often excluded from trials. As a result, drugs that look effective in studies sometimes perform poorly in hospitals all because we didn’t choose the right subjects. This gap has pushed regulators to accept real world evidence collected from electronic health records and routine clinical care which are not at all reliable resources when it comes to taking toxicology data of certain drugs. Instead of asking whether a drug works in ideal conditions, healthcare is beginning to ask whether it works in everyday life. This shift may feel uncomfortable to scientists, but it reflects reality. Evidence that comes from real people may be messy, but it is also more honest.

What are your thoughts on this ?

MBH/PS

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ideal evidence gives confidence, real-world evidence gives truth. Modern healthcare needs both used carefully, critically, and together.

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Clinical trials that include real-world patients can be fruitful due to the challenges they have overcome.

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This highlights a real problem in medicine. Drugs may perform well in controlled trials, but real patients are far more complex and rarely fit ideal conditions. Real-world evidence is imperfect and messy, yet it reflects how treatments actually work in everyday practice. Balancing rigorous clinical trials with real-life data is essential to make healthcare decisions more realistic, patient-centered, and effective beyond paper results.

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