Why are gallstones more common in women

Cholelithiasis is the medical term for gallbladder stones. The gallbladder is located in the abdomen below the liver. The main function of the gallbladder is to transport bile juice into the small intestine.

Gallstones are formed when bile juice hardens and forms hard stones, obstructing the bile duct. As a result, the transport of bile to the small intestine is hindered. The stones can be cholesterol stones due to increased levels of cholesterol (common in females https://www.thehindu.com/sci-tech/health/why-do-gallstones-affect-women-more-pregnancy-is-also-a-risk-factor-say-experts/article70665874.ece during pregnancy) or pigment stones, which contain bilirubin.

Gallstones are more common in females due to oestrogen levels, which can increase during pregnancy and hormonal therapy. They can also be common in females who are obese. So, it is said that fat, fertile females around 40 years of age are prone to gallstones.

Gallstones can be symptomatic or asymptomatic. Asymptomatic gallstones are called silent stones. The size of the stones can range from as small as a grain of sand to as big as a golf ball. Tiny stones sometimes cause more pain.

Symptoms of Cholelithiasis are:

  1. Abdominal pain immediately after eating
  2. Bloating
  3. Nausea
  4. Vomiting
  5. Radiating pain to shoulder blade
  6. Indigestion

In the case of pregnant women, if gallstones are not causing trouble, they can be left as is. If surgery is needed, it can be performed in the second trimester, as it is considered safe.

Investigations:

  1. Ultrasound of abdomen
  2. CT
  3. MRI

Treatment:

Gallstones are generally not dangerous, but when they cause problems, they must be treated.

  1. Small stones can be treated with oral medication, though it’s time-consuming.
  2. Cholecystectomy — removal of the gallbladder — in cases where the stones are causing pain or jaundice.

Have you seen female patients with cholelithiasis in your OPDs?Share your views.

MBH/AB

1 Like

Recently, I saw a 68-year-old male patient who underwent a laparoscopic cholecystectomy and was subsequently discharged.

2 Likes

I myself had small gall stones during postpartum period. With lifestyle modification including diet and yoga, subsequent scans turned out to be normal.

1 Like

Gallstones are significantly more common in women because of higher estrogen level that increase cholesterol in bile and reduce gallbladder movement. Pregnancy, oral contraceptives, and hormone replacement therapy further contributes to this risk,

2 Likes

Mentioning that gallstones can be asymptomatic (“silent stones”) is valuable, as many people may not realize they can have gallstones without symptoms.

2 Likes

Great post! By creating awareness among females can reduce the risk of gallstone and helps to Early diagnosis

1 Like