Semaglutide : Drug Profile

Pharmacy
1

semaglutide-injection-1mg
semaglutide-injection-1mg1280×960 59.3 KB

Drug Profile: Semaglutide

Drug Class: Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist

What is Semaglutide?

Semaglutide is a long-acting GLP-1 receptor agonist. They are used to treat type 2 diabetes mellitus and for chronic weight management. Semaglutide has emerged as a cornerstone therapy for managing metabolic disorders by improving glycemic control and promoting weight loss.

Mechanism of Action

Semaglutide enhances glucose-dependent insulin secretion, suppresses glucagon release, and delays gastric emptying. These actions contribute to reduced calorie intake and improved blood glucose control.

Indications

  • Type 2 Diabetes Mellitus
  • Chronic weight management in adults with obesity or overweight
  • Reduction of cardiovascular risk in selected patients with type 2 diabetes

Adverse Events

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Decreased appetite

Drug Interactions

  • Insulin and sulfonylureas: Concurrent use may increase the risk of hypoglycemia.
  • Oral medications: Semaglutide delays gastric emptying and may affect the absorption of some orally administered drugs.
  • Warfarin: Changes in INR have been reported. Monitoring is recommended when initiating semaglutide therapy.
  • Other Antidiabetic Agents: Combined use may enhance glucose-lowering effects.

Precautions

Patients should be counseled about gastrointestinal side effects. Semaglutide should be used cautiously in patients with a history of pancreatitis.

Semaglutide improves glycemic control, promotes weight loss, and reduces cardiovascular risk.

MBH/DB

2

These days Semaglutide is used in weight management. People are using these for weight management. Overuse can result in thyroid tumour, pancreatitis , kidney problems

3

GLP-1 drugs are been marketed in e-commerce.
Many are not aware of the side effects .
A proper prescription is mandatory.

4

benefits of therapy with semaglutide are,

  1. Lowers Hemoglobin A1c by approximately 1–2%.
  2. Produces significant weight loss, often 10–15% or more with higher-dose obesity treatment alongside lifestyle changes.
  3. Reduces major adverse cardiovascular events in people with type 2 diabetes and established cardiovascular disease.
  4. Has also demonstrated cardiovascular benefit in certain adults with obesity and established cardiovascular disease, even without diabetes.