https://jamanetwork.com/journals/jama/fullarticle/2839213
Traditionally used to treat allergic rhinitis, azelastine has also shown antiviral activity against respiratory viruses, including several SARS-CoV-2 variants. To test its efficacy in preventing infection, researchers at a hospital in Germany randomly assigned 450 participants to receive either azelastine spray or a placebo 3 times per day for about 2 months. The findings revealed that participants who used azelastine were significantly less likely to test positive for COVID-19: 2% had confirmed illness vs 7% in the placebo group.
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