How the Widely Used Medicine Works: Cetirizine

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Cetirizine is a widely used medicine that helps relieve symptoms of allergic reactions and acts as a potent antihistamine. But what is the mechanism of action of cetirizine?

During an allergic reaction, mast cells release histamine, which produces common allergic symptoms, including runny nose, redness, swelling, sneezing, and itching.

Cetirizine blocks H₁ histamine receptors, inhibiting the effects of histamine released during allergic reactions. This reduces vasodilation, capillary permeability, and sensory nerve stimulation, leading to decreased allergic symptoms.

Uses of cetirizine -
* Chronic Urticaria (Hives)
* Skin Allergic Reactions
* Allergic rhinitis

Side effects of cetirizine -
* Fatigue
* Dry mouth
* Headache
* Mild drowsiness

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It’s informative! Cetirizine is a very common drug taken for allergic reaction. Cetirizine is generally taken once daily and can be administered with or without food. It can cause severe drowsiness when taken over dose so should be taken carefully.

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