Anemia is the most common condition seen in almost everyone these days but more prevalent among women.The etiology of anemia ranges from nutritional deficiencies to hereditary reasons. There are different types of anemias based on the etiologies.The treatment involves Iron tablets,Vitamin supplements (B12,folate) and dietary changes for deficiences.In severe cases,blood transfusions and Erythropoietin injections are used.
The GI-related issues with iron supplementation leads to non-adherence in many patients with anemia.
There’s an emergent treatment for anemia which are the Hypoxia-Inducible Factor Prolyl Hydroxylase inhibitors (HIF-PH inhibitors). They include drugs like desidustat, roxadustat, daprodustat.These drugs trick the body into thinking it’s in a hypoxic state and then stabilize the HIFs by blocking HIF-PH enzymes which in turn triggers genes for EPO production and iron absorption.These drugs are used especially in CKD-induced anemia and for many other applications.
Have you ever come across this new treatment for anemia and what are the drugs from this class that are FDA approved and are under clinical trails?
MBH/AB