From " NASH" to "MASH"

General
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Non-alcoholic steatohepatitis is now called as Metabolic dysfunction associated steatohepatitis, to promote wider understanding of the disease.It includes metabolic dysfunction marked by diabetes , insulin resistance, obesity , hyperlipidemia and hypertension.
It reduces stigma around world alcohol and better understanding of underlying cause.
It is reversible in early stages with 10 %weight loss, Mediterranean diet and risk factor control.
It is a stage after fatty liver characterisied by liver inflammation and injury.If left untreated can progress to liver scaring ( fibrosis) , cirrhosis and liver cancer.
It is expected to become leading cause of cirrhosis in coming years, leaving alcoholic cirrhosis and viral ( hepatitis C and B) hepatitis behind.
Many drugs like semaglutide and Resemtirom are under trial for MASH management along with life style modification.

Do you think lifestyle modification is enough to control this silent pandemic or medicine will play a bigger role?

MBH/AB

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Nutraceuticals and nutritional management have shown really good results in multiple clinical trials involving MASH.

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i think both will be needed to maintain proper health.

Lifestyle modification also and medicine also.

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The shift from NASH (Non-Alcoholic Steatohepatitis) to MASH (Metabolic dysfunction-Associated Steatohepatitis) reflects a more precise understanding of the disease’s root cause. By emphasizing metabolic dysfunction, the new terminology reduces stigma, improves clarity in diagnosis, and highlights the strong link between liver health, obesity, diabetes, and metabolic syndrome. It’s not just a change in name, but a step forward in aligning clinical practice with underlying science.

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Obviously lifestyle change will help ,in making the condition better ,it’s all about what we decide to do and bring changes

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