B.
TNF-α inhibitors is called as game changer in autoimmune diseases because, In a autoimmune diseases there is increase in TNF-α at the head of cytokine which leads to inflammation, TNF-α inhibitiors binds with TNF-α and controls the symptoms, with low side effects.
TNF-α inhibitors target central inflammatory pathway and substantially reduce symptoms, prevent irreversible damage, and restore function in several autoimmune diseases. They are thus considered as Game changers in autoimmune diseases.
Ans is TNF alpha
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