The 2025 Nobel Prize in Medicine was awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for the discoveries about peripheral immune tolerance.
Immune tolerance is ability of immune system to avoid attacking its own cell and tissue. It works at two level central ( during immune development) and peripheral ( immune system matured in secondary lymphoid organ like lymph node ,spleen , blood and entered circulation).
They discovered REGULATORY TCELL role in preventing autoimmunity. The key transcription factor is FOXP3 ,which regulates regulatory T cell function and development.
If any regulatory T cell function or number is lost , it can lead various autoimmune disease like SLE, IPEX syndrome, Rheumatoid arthritis , type-1 diabetes and many more.
Knowing this help us in understanding autoimmune disorder and cancer in which immune system is hijacked and safe response to infections better .
If in future scientist can boost regulatory T cell safely . Do you think it can be potential preventive management of autoimmunity , cancer and regulating infection?
FoxP3 is a critical transcription factor for regulatory T cells (Tregs) that maintains immune self-tolerance, and its dysfunction or mutation leads to impaired Treg function, contributing to the development of autoimmune diseases by allowing immune attack on self-tissues.
FOXP3 is such a game changer in immunology! Strengthening regulatory T cell function could indeed transform the way we approach autoimmune and cancer therapies.
Absolutely! Safely boosting Tregs could be a game-changer, offering preventive control over autoimmunity, cancer, and infections by restoring immune balance
Autoimmune disorder is a bane in the medical field. Our own body is very aggressive in eliminating any foreign substance from our body. This is, in fact, observed that when the eye becomes damaged and the fluid seeps out, our body doesn’t understand that these are our own cells and may cause destruction of the eye, causing blindness. Such a discovery could help in treating numerous autoimmune disorders quickly.
Yes safely boosting regulatory T cells (Tregs) could be a game changer. It may help prevent or control autoimmunity, fine tune immune responses in cancer, and maintain balance during infections if achieved without suppressing protective immunity.