Drug Of The Week Series - 25.1

Pharmacy
1
Brivaracetam exerts it’s epileptic activity by which mechanism
  • Increases the inhibitory effects of GABA
  • Binds to synaptic vesicle protein (SV2A) and reduces release of excitatory neurotransmitters
  • Prolongs inactive state of voltage-gated sodium channels, suppressing repetitive firing of neurons
  • Block T-type calcium channels in thalamic neurons
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Can you name a few other anti-epileptic drugs ?

MBH/PS

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2

Phenytoin:- focal/generalized tonic-clonic

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3

Other anti-epileptic drugs include Carbamazepine, phenobarbitone,clonazepam

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4

Carbamazepine is DOC for?

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Carbamazepine is usually effective in treating complex partial seizures.

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In neonates, we still use phenobarbital as first line of drug in case of seizures.

Levetiracetam is often used if we need for prolonged use. Never used Brivaracetam.