Drug of the week series - 24.1

[dr_sneha_p]

Which component of cotrimoxazole specifically targets dihydrofolate reductase and what is its primary anti-microbial action when used alone?

• Trimethoprim; bactericidal
• Sulfamethoxazole; bactericidal
• Trimethoprim; bacteriostatic
• Sulfamethoxazole; bacteriostatic

Question:

Is cotrimoxazole bacteriostatic or bactericidal in action?

Can you mention other fixed-dose combination antibiotics?

Comment your answers !

MBH/PS

[sumana]

bacteriostatic action.

[jyothi_412]

bactericidal action, kills bacterial infection

[Vaishnavi_13]

Bactericidal in action

[vidhi12]

It is bactericidal. Few fixed dose combinations include: amoxicillin/clavulunic acid, cefoperazone/sulbactam, ceftazidime/avibactam.

[Aniket]

Amoxicillin + clavulanic acid — β-lactam + β-lactamase inhibitor.