Drug of the week series - 21.3

A patient who was on naltrexone develops severe pain after an emergency procedure. The medical team suggested to use opioid analgesics to relieve him from pain. Can you tell the most important factor to be taken under consideration before prescribing the same?

  • A. Naltrexone may block the analgesic effects of opioids
  • B. Naltrexone enhances opioid analgesia
  • C. Naltrexone should always be stopped and replaced with methadone
  • D. There is no interaction between naltrexone and opioids
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Answer to the day 2 poll (21.2) poll: B. Confirm an adequate opioid-free period before starting

MBH/PS

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Naltrexone is an opioid antagonist meaning it blocks the receptors opioids bind to, so opioids as analgesia wouldn’t work for this patient anymore.