This week, we explored Latanoprost, a Prostaglandin F₂α (PGF₂α) analogue and a first-line medication used in the management of Primary Open-Angle Glaucoma (POAG) and ocular hypertension.
Mechanism of Action (MOA)
• Increases uveoscleral outflow of aqueous humor
• Reduces intraocular pressure (IOP)
Clinical Uses
• Primary Open-Angle Glaucoma (POAG)
• Ocular hypertension
Administration
• Administered once daily, preferably at night
Common Adverse Effects
• Iris pigmentation (brown discoloration)
• Conjunctival hyperemia
• Periorbital skin pigmentation
• Increased eyelash growth (hypertrichosis)
Contraindications / Use with Caution
• Active uveitis
• Herpetic keratitis
• Aphakia or pseudophakia with risk of cystoid macular edema
MBH/PS