CAUSES OF CUSHING SYNDROME !!!!

General
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Mnemonic

( C U S H I N G )

C :- CORTICOSTEROIDS

U :- UNCOMMON TUMORS

S:- SMALL CELL LUNG CARCINOMA

H:- HYPERPLASIA

I :- IATROGENIC

N:- NEOPLASM

G:- GLUCOCORTICOID SECRETING TUMOR

Can you list out more ???

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Know the difference between Cushing syndrome and Cushingoid Syndrome (latter due to steroid meds).
And remember Cushing facies.

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Most common is iatrogenic ( due to intake of steroids)
Pituitary adenoma, ectopic ACTH secretive tumor

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Most common exogenous cause of cushing syndrome is prolonged use of corticosteroids like prednisolone for asthma or other autoimmune diseases.

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Cushing’s syndrome is caused by excess cortisol levels, which can result from:

  1. Prolonged use of corticosteroid medications
  2. Pituitary tumors (Cushing’s disease)
  3. Adrenal gland tumors or hyperplasia
  4. Ectopic ACTH-producing tumors (e.g., lung cancer)

These conditions lead to an overproduction of cortisol, causing characteristic symptoms like weight gain, hypertension, and mood changes.

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