Case 28: Always Thirsty

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A 22-year-old man complains of excessive thirst and frequent urination. His fasting glucose is 98 mg/dL, serum sodium is 150 mEq/L, and urine osmolality is low.

Question:
What is the next best step to differentiate between central and nephrogenic diabetes insipidus?
A. Serum ADH level
B. Water deprivation test
C. IV dextrose test
D. Serum cortisol test

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Water deprivation test.

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Thank you! Nice information.

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Thank you.

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Disease - Diabetes Insipidus
Trick to identify - excessive thirst, frequent urination , high serum sodium with low urine osmolarity
The next best step to differentiate between central and nephrogenic diabetes is water deprivation test