Antibiotic resistance refers to the capacity of bacteria to survive or grow despite exposure to concentrations of antibiotics that would normally inhibit or kill them
What is anti-biotic?
Antibiotics are substances produced by microorganisms or their derivatives that, in low concentrations, inhibit the growth of or destroy other microorganisms
Classification of antibiotics
Uses of antibiotics
- Treatment of bacterial infections
- Prophylaxis in surgery
- Management of life-threatening infections
Mechanism of action:
ANTIBIOTICS
↓
Act on Bacterial Cell
↓
- Inhibit Cell Wall Synthesis
- Inhibit Protein Synthesis
- Inhibit Nucleic Acid Synthesis
- Inhibit Metabolic Pathway
- Damage Cell Membrane
↓
Bacterial death / Growth inhibition
So what happens when antibiotics resistance occurs
ANTIBIOTIC RESISTANCE
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Bacterial Adaptation
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- Enzymatic Inactivation of Drug
- Alteration of Target Site
- Reduced Drug Entry
- Efflux Pump Activation
- Bypass of Metabolic Pathway
↓
Antibiotic becomes ineffective
Causes of antibiotics resistance
- Overuse of antibiotics
- Incomplete treatment course
- Wrong dose / wrong drug
- Self-medication
- Use in viral infections
Prevention of anti biotic resistance
**
- Use antibiotics only on prescription
- Complete full course
- Correct dose & duration
- Avoid self-medication
- Maintain hygiene & infection control
Antibiotic resistance is a serious health issue caused by improper use of antibiotics. Responsible use and awareness are essential to prevent it.
What is your opinion on antibiotic resistance?
MBH/PS