WHY ACE INHIBITORS ARE AVOIDED IN PREGNANCY

General
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WHY ACE INHIBITORS ARE AVOIDED IN PREGNANCY

What are ACE Inhibitors

It is commonly prescribed for hypertension, heart disease and kidney disorders. Examples include Enalapril, lisinopril, ramipril etc…
General mechanism of ACE inhibitors

It blocks the renin-angiotensin-aldosterone system by inhibiting conversion of angiotensin I and angiotensin II

Normal fetal physiology
Angiotensin II is essential for the maintaining fetal blood pressure, supporting renal development, regulating fetal urine protection. Fetal urine need for the amniotic fluid in the 2nd and 3rd trimesters.

Reason for ACE inhibitors avoided in pregnancy

Mechanism
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While ACE inhibitors are administered by the pregnant women it can lead to the blockage of angiotensin II which is essential for the renal development, urine production in foetus and the blockage result in low amniotic fluid and it can cause the poor lung development, renal failure, fetal growth restriction.

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Clear and important! ACE inhibitors can harm fetal development, so safer alternatives are preferred during pregnancy. Awareness of this helps protect both mother and child.

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very imprtant.. avoid ACE inhibitors in pregnancy

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Safer alternatives should be preffered like labetalol, nifedipine etc.

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informative article. In pregnancy taking any medicine without consulting doctors can be harmful as they have varied effect on fetuses than us.