In the science of drug discovery, we have seen two breakthroughs: one being nanotechnology, where nanodrug particles with better drug availability help us deliver medicines more effectively, and the other being lipid-based drug molecules, which show better bioavailability, absorption, and efficacy.
And what if both these technologies are combined? Yes, that has already been done and these molecules are called nanocochleates.
Nanocochleates are cylindrical, cigar-shaped structures made from negatively charged lipids and divalent cations (like calcium). Their unique rolled lipid bilayer structure allows them to encapsulate both hydrophilic and hydrophobic drugs, protecting them from harsh gastrointestinal conditions and improving drug stability and bioavailability.
What is new!?
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Enhance the oral bioavailability of poorly soluble drugs
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Protect sensitive molecules like proteins, peptides, genes, and vaccines
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Provide controlled and sustained drug release
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Reduce toxicity and side effects
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Offer excellent stability, even after lyophilization
Applications
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Cancer therapy (e.g., paclitaxel, doxorubicin)
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Diabetes management (e.g., insulin, resveratrol)
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Antifungal and antiviral treatment (e.g., amphotericin B, nelfinavir)
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Vaccines, gene delivery, and nutraceuticals
With the above description, we can definitely say that nanocochleates will be a great revolution.
What are your thoughts?? Will nanocochleates be a revolution or get lost among the many already present?
Have you ever seen them being used in clinical practice?
MBH/PS