“Not all the weight gains are lifestyle-related, sometimes it’s prescribed.”
Weight gain is often attributed to lifestyle choices, but an overlooked contributor is medication induced metabolic change. Several commonly prescribed drugs can unintentionally promote weight gain by altering appetite regulation, energy expenditure, insulin sensitivity and fat storage. This effect not only impact physical health but also affect mental well-being, treatment adherence and long-term outcomes.
Steroids are well-known to increase appetite, promote central fat deposition and cause fluid retention.
Antidepressants and Antipsychotics may interfere with neurotransmitters involved in satiety and reward pathways leading to increase caloric intaken. Certain antiepileptics and hormonal therapies can reduce basal metabolic rate or induce insulin resistance. Even long-term use of asthma medications and beta-blockers has been associated with gradual weight changes in some patients.
Drug induce weight gain is not merely a cosmetic concern. It increases the risk of diabetes, cardiovascular disease and poor medication compliance as patients may discontinue therapy without medical advice. Unfortunately, this adverse effect is offen under discussed during prescribing.
Recognising medication related weight gain early allows clinicians to counsel patient, consider alternative therapies, adjust doses and integrate lifestyle interventions. A patient centered approach that balances therapeutic benefit with metabolic impact is essential to improve adherence, trust and overall quality of care.
Are there any specific management of most common inhaled corticosteroid-induced weight gain?
MBH/AB