Have you ever wondered why stomach pain or burning sensation happens even when you haven’t eaten anything spicy?
A peptic ulcer is a condition where the inner lining of the stomach or intestine gets damaged, forming a sore or wound.
This usually happens because of an imbalance between aggressive factors and defensive factors inside our stomach.
The Stomach Balance System
Aggressive Factors (Damage Makers)Peptic Ulcer Disease: When Stomach Defense Fails
• Excess stomach acid
• Pepsin enzyme
• Long-term use of NSAIDs (painkillers)
• Helicobacter pylori bacterial infection
Defensive Factors (Protection System)
• Mucus layer protecting the stomach wall
• Bicarbonate secretion
• Prostaglandins that maintain stomach lining health
When aggressive factors become stronger than defensive protection → ulcer develops.
Treatment of Peptic Ulcer (Simple Classification)
Gastric Acid Secretion Inhibitors (H₂ Blockers)
Reduce acid production
Examples: Cimetidine, Ranitidine, Famotidine
Anticholinergic Drugs
Decrease acid stimulation
Examples: Propantheline, Pirenzepine, Oxyphenonium
Proton Pump Inhibitors (PPIs)
Strong acid blockers that allow healing
(Example group: Omeprazole-type drugs)
Prostaglandin Analogues
Improve natural stomach protection
Gastric Neutralizers (Antacids)
Neutralize already formed acid
• Systemic antacids
• Non-systemic antacids
Why This Matters?
Ignoring repeated acidity or stomach pain may lead to ulcers and serious complications. Proper diagnosis and medication guidance are essential.
Do you think stress, lifestyle, or medicines play the biggest role in causing stomach ulcers today?
MBH/PS