Organoids is simplified versions of organs grown in vitro from stem cells that have same structural and functional properties of real organs.
We are living in a world ,where we can grow small versions of your brain, liver or other organs in a dish ; not for fiction, but for real medicine.
Unlike conventional cell cultures, organoids can self-organize itself , make communication, and even perform some organ-specific tasks like secreting hormones, excreting toxin and many more. They are made up of pluripotent stem cells ( cells capable of becoming any tissue ) with the sufficient nutrients, growth factors, and a 3D environment (like Matrigel), these cells self-assemble into organ-like structures.
We can grow organoids from a patient’s own cells to test which drug works best before actual treatment .
They help recreate diseases, allowing researchers to study genetic mutations or infection patterns. They can bridge the gap between animal models and human trials, predicting drug response more accurately.
Despite their promise, they are not perfect. They lack blood vessels and immune systems, limiting their growth .Cost and reproducibility is a big hurdle in widespread clinical use.
“What if your doctor could test drugs on a mini copy of your liver before prescribing one to you — would that change medicine forever?”
https://www.mdpi.com/2674-1172/4/3/16?utm_
MBH/AB