In Intrauterine life Neurons releasing GnRH are in Olfactory epithelium.
They normally migrate to hypothalamus along with olfactory nerve.
Failure of this neuronal migration cause Kallmann syndrome.
X-linked recessive disorder
KAl-1 gene involved
Males > Females
Clinical features:
Decreased GnRH - Decreases LH and FSH
- Decreased Estrogen in Femlaes - Primary Anmenorrhea
- Decreased Androgen in males
- causing Delayed puberty, Infertility
- Hyposmia / Anosmia
- Normal Height
Management: Pulsatile GnRH