The carrageenan-induced paw edema model is a experimental method to study inflammation and pain in laboratory animals. Injection of λ-carrageenan into the rat’s hind paw produces inflammatory response through the release of mediators like histamine, serotonin, and prostaglandins.
Carrageenan produces a biphasic inflammatory response:
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Phase I (0–2 hours): mediated by histamine, serotonin, and bradykinin.
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Phase II (3–5 hours): primarily prostaglandin- and cytokine-mediated.
Its sensitivity to NSAIDs and other anti-inflammatory agents continues to make it a gold standard in preclinical testing.
In the carrageenan-induced pain model, different mediators dominate the first and second phases of inflammation. Do you think this distinction is pharmacologically important?
https://pubmed.ncbi.nlm.nih.gov/5776026/
MBH/PS