From Olive Oil to Oncology: How 2-OHOA and Oleocanthal Show Promise Against Cancer

General
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Olive Oil–Derived Compounds in Cancer Research

One promising drug candidate, 2-hydroxyoleic acid (2-OHOA), is a synthetic derivative of oleic acid, a major component of olive oil. Research has shown that 2-OHOA can disrupt cancer cell membrane signaling pathways, thereby inhibiting the growth of aggressive tumors such as glioblastoma.

In addition to 2-OHOA, other olive oil–derived compounds are under scientific investigation:

  • Oleocanthal → A natural phenolic compound with anti-inflammatory and anti-cancer properties. It has been shown to induce cancer cell death selectively while sparing healthy cells.

  • Polyphenols from extra virgin olive oil (EVOO) → These compounds demonstrate antioxidant, anti-inflammatory, and potential chemopreventive effects. Ongoing studies suggest they may act as co-adjuvant therapies, enhancing the efficacy of existing cancer treatments.

Together, these findings highlight olive oil not only as a cornerstone of the Mediterranean diet, but also as a source of bioactive molecules with pharmaceutical potential. Continued research may unlock new strategies for managing cancer and inflammatory diseases.

MBH/AB

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Informative

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It’s exciting to see how compounds from olive oil are showing real promise in fighting cancer and supporting overall health through natural, science-backed mechanisms!

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Olive oil compounds like 2-OHOA and oleocanthal show promise against cancer. 2-OHOA disrupts tumor cell signaling, slowing growth in aggressive cancers, while oleocanthal selectively kills cancer cells. Polyphenols in extra virgin olive oil may enhance existing treatments with antioxidant and anti-inflammatory effects.