FFP VS Cryptoprecipitate ... Who will win ??

MBBS
1

FFP and Cryptoprecipitate both are the sources of fibrinogen used during secondary PPH in order to maintain >100mg/dl of fibrinogen due to blood loss.

However topic of discussion still remains , which one is a better source for fibrinogen transfusion… ??

FFP :- containing all the clotting factors can be used during chronic bleeding conditions.

Whereas

Cryptoprecipitate :- have limited factors like factor VIII, XIII and vWF again used for chronic bleeding disease.

Why do u think that doctors prefer Cryptoprecipitate over FFP ??
Since the major criteria to control secondary PPH is stopping the bleeding first and FFP has all the factors required …!!

2

Doctors prefer cryoprecipitate over FFP in secondary PPH :-
Generally when it need to avoid large volume transfusion.
It also conrtibutes and essential for control bleeding.
And isolates the abnormal low levels of fibrinogen.

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3

It prefer Cryoprecipitate over FFP in secondary PPH. Because, It provides a more volume efficient and rising fibrinogen.

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4

Doctors prefer Cryoprecipitate over FFP in secondary PPH because:

  • It has more concentrated fibrinogen, critical for clot formation.
  • Requires less volume (reducing fluid overload).
  • Acts faster for targeted correction of coagulopathy.
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5

The choice between cryoprecipitate and FFP depends on the specific coagulation factor deficiencies and the clinical scenario.

In PPH, if there’s a significant drop in fibrinogen levels, cryoprecipitate might be preferred to rapidly restore fibrinogen.

FFP might be used more broadly for correcting multiple coagulation factor deficiencies. Guidelines and institutional protocols often guide the specific use.

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6

FFP (Fresh Frozen Plasma) and cryoprecipitate are both blood products used to manage bleeding disorders, but they serve different purposes.

FFP contains all clotting factors, while cryoprecipitate is rich in fibrinogen, factor VIII, and von Willebrand factor.

  • FFP might be preferred for broad clotting factor replacement or reversing warfarin anticoagulation.
  • Cryoprecipitate might be chosen for fibrinogen replacement or managing specific factor deficiencies.
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