Drug induced hyperprolactinemia:an oftern overlooked adverse effect

Pharmacy
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Hyperprolactinemia which is increase in level of sr.prolactin in our body.Generally we have seen this increase in levels during pregnancy, hypothyroidism conditions.

Drug induced hyperprolactinemia:

This is caused by the medication that reduces the dopamine activity,as dopamine normally inhibits the prolactin secretion from the pitutary gland.

The culprit drugs that causing this condition are Antiphyschotics,Antidepressants, Antiemetics …

The symptoms that may faced by the people during this period includes Galactorrhea, primary dysmenorrhea, Amenorrhea, Long term risk of decreased bone mineral density

So always review a patients past medical history before evaluating the other causes for elevated prolactin levels. Recognising this drug induced hyperprolactinemia help to prevent unnecessary investigations and guide appropriate treatment.

Have you ever encountered such cases?

MBH/PS

6 Likes
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Informative!! Mostly dopamine antagonists (especially risperidone and metoclopramide) are the most common drug-induced causes of hyperprolactinemia.

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Thanks for sharing; worth reading. Not only for the risk of hyperprolactinemia, but also giving a prescription by reviewing a patient’s medical history is always a must, as providing a patient with a prescription for certain drugs without review of prior medical history may cause other medical complications too.

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Very informative. Medication history can save patients from unnecessary investigations and anxiety. Drug induced hyperprolactinemia is easy to miss.

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5

Very informative post. But sometimes a medical condition like a prolactinoma (a non-cancerous tumor) can create hyperprolactinemia too.

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6

An important reminder that medications can significantly influence hormone levels. A thorough medication history is essential before considering other causes of hyperprolactinemia.

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This information is useful for healthcare professionals, researchers, and students to understand the role of prolactin in the body and recognize the clinical implications of hyperprolactinemia. It helps in early identification, accurate diagnosis, and effective management of hormonal and reproductive disorders

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8

As a Pharm.D student, I’ve learned that drug-induced hyperprolactinemia is more common than many people realize, especially with certain antipsychotics and antiemetics. Although I haven’t encountered Case personally, it has reinforced the importance of reviewing a patient’s medication history before considering more invasive investigations

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9

Drug-induced hyperprolactinemia is something that’s easy to overlook if we don’t take a thorough medication history. It’s a good reminder that not every abnormal lab value points to a new disease—sometimes the answer is already in the patient’s prescription list.

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Informative post, high prolactin is also antagonistic to insulin and can cause insulin resistance.

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Very informative post! Drug-induced hyperprolactinemia can easily be overlooked when evaluating elevated prolactin levels. Reviewing a patient’s medication history is an important step in identifying the cause and avoiding unnecessary investigations.