A 21 yr old male Presents to the ER with slurred speech and right hemiparesis. On ausculataion, a systolic murmur at the pulmonic region and a diastolic rumble along the left sternal border is heard. S2 is split and fixed. What is the cause of these symptoms?
The fixed, wide split S₂ alongside a systolic ejection murmur and a diastolic rumble points strongly toward Atrial Septal Defect (ASD). The neurological symptoms slurred speech and right-sided weakness in a young patient likely result from a paradoxical embolism, where a clot travels through the septal defect into the arterial circulation and reaches the brain.
The answer is ASD. Symptoms such as slurred speech and hemiparesis are likely due to a paradoxical embolus leading to acute embolic stroke. The embolus is paradoxical as a venous thrombus usually from the legs or pelvic region pass to the central circulation through a septal defect, mostly an ASD can sometimes be a VSD. A mid systolic murmur in ASD is due to increased flow across the pulmonic valve.
A diastolic rumble is due to increased flow across the tricuspid valve.