# Must know deadly drug combination  **URL:** \ **Category:** General\ **Tags:** mbbs, medical\ **Created:** [May 20, 2026, 11:44am UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980 "2026-05-20T11:44:44Z")\ **Posts on this page:** 13\ **Page:** 1
**Author:** ![DrPal\_28](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/drpal_28/32/4329_2.png) [@DrPal\_28](https://www.medboundhub.com/u/DrPal_28)\ **Post date:** [May 20, 2026, 11:44am UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/1 "2026-05-20T11:44:44Z")
**Metronidazole + Alcohol** : Symptoms include severe nausea, vomiting, flushing, fast heartbeat, and headaches. You should avoid alcohol during treatment and for at least 72 hours after the last dose. **Iron + Antacids** : Significantly reduces iron absorption because iron requires an acidic environment to dissolve. **Gentamicin + furosemide** : Carries a significant risk of severe, often irreversible, ear and kidney damage, including sensorineural hearing loss, vertigo, and acute kidney injury **Digoxine + furosemide** : Furosemide, a diuretic, lowers potassium and magnesium levels, which can make the heart more sensitive to digoxin, leading to serious arrhythmias. **Aspirin + warfarin** :Greatly increases the risk of serious bleeding. **Ceftriaxone + calcium** : Create fatal, insoluble precipitates in the lungs and kidneys Not every dangerous drug reaction comes from the disease, sometimes it comes from the prescription itself. Suggest other drug combination to avoid. ---
**Author:** ![Snazir](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/snazir/32/4968_2.png) [@Snazir](https://www.medboundhub.com/u/Snazir)\ **Post date:** [May 20, 2026, 2:32pm UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/2 "2026-05-20T14:32:51Z")
NSAIDS and Anti-coagulants in general are deadly combinations to be avoided. ---
**Author:** ![Ashana](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/ashana/32/4680_2.png) [@Ashana](https://www.medboundhub.com/u/Ashana)\ **Post date:** [May 20, 2026, 2:40pm UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/3 "2026-05-20T14:40:03Z")
ACE inhibitors and potassium supplements increase the risk of hyperkalemia. ---
**Author:** ![Shreyas1](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/shreyas1/32/4638_2.png) [@Shreyas1](https://www.medboundhub.com/u/Shreyas1)\ **Post date:** [May 20, 2026, 3:44pm UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/4 "2026-05-20T15:44:03Z")
Informative ! - Sildenafil + Nitrates (nitroglycerin) - Linezolid + SSRIs (fluoxetine/sertraline) - MAO inhibitors + Tyramine-rich food are also dangerous combinations ---
**Author:** ![Madiha\_Khan](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/madiha_khan/32/4384_2.png) [@Madiha\_Khan](https://www.medboundhub.com/u/Madiha_Khan)\ **Post date:** [May 21, 2026, 6:22am UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/5 "2026-05-21T06:22:28Z")
Very important and clinically relevant topic.Drug interactions are often underestimated, even though some combinations can lead to serious complications. Other Drug Combinations to Avoid: • Sildenafil + Nitroglycerin → severe hypotension • ACE inhibitors + potassium supplements → hyperkalemia ---
**Author:** ![UrvaD](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/urvad/32/4764_2.png) [@UrvaD](https://www.medboundhub.com/u/UrvaD)\ **Post date:** [May 21, 2026, 6:37am UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/6 "2026-05-21T06:37:27Z")
**Statins(Simvastatin) + certain antifungals** **(Ketoconazole)** is a strictly contraindicated drug interaction I know about.It can cause severe muscle toxicity and a dangerous condition rhabdomyolysis. ---
**Author:** ![Harshini\_13](https://avatars.discourse-cdn.com/v4/letter/h/e99b99/32.png) [@Harshini\_13](https://www.medboundhub.com/u/Harshini_13)\ **Post date:** [May 21, 2026, 7:02am UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/7 "2026-05-21T07:02:16Z")
**Tetracycline antibiotics + Calcium** - Calcium ions bind to the tetracycline molecules and form insoluble complex that cannot be absorbed into the blood stream through gastrointestinal trcat. **Clarithromycin + Calcium channel blockers** - Increases the risk of hypotension. ---
**Author:** ![GRL](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/grl/32/4296_2.png) [@GRL](https://www.medboundhub.com/u/GRL)\ **Post date:** [May 21, 2026, 8:01am UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/8 "2026-05-21T08:01:06Z")
Such an informative post. Thanks for sharing 🙂 ---
**Author:** ![DrPreya\_28](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/drpreya_28/32/4391_2.png) [@DrPreya\_28](https://www.medboundhub.com/u/DrPreya_28)\ **Post date:** [May 22, 2026, 5:51pm UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/9 "2026-05-22T17:51:49Z")
Informative post. ---
**Author:** ![Aditi\_j](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/aditi_j/32/4664_2.png) [@Aditi\_j](https://www.medboundhub.com/u/Aditi_j)\ **Post date:** [May 22, 2026, 6:30pm UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/10 "2026-05-22T18:30:49Z")
Very useful information. Deadly drug combination i know is Metformin + alcohol use : can cause lactic acidosis. Paracetamol ( overdosed) + cold / pain medication : increased liver toxicity. ---
**Author:** ![Dawoodfayazmalik](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/dawoodfayazmalik/32/5833_2.png) [@Dawoodfayazmalik](https://www.medboundhub.com/u/Dawoodfayazmalik)\ **Post date:** [May 25, 2026, 11:26am UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/11 "2026-05-25T11:26:24Z")
Deep knowledge includes in this article! Very interesting ---
**Author:** ![drShah\_31](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/drshah_31/32/4703_2.png) [@drShah\_31](https://www.medboundhub.com/u/drShah_31)\ **Post date:** [May 25, 2026, 1:38pm UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/12 "2026-05-25T13:38:05Z")
Thanks for highlighting this information which is a very important aspectswhen delivering health care in prescribing medicines without this forethought of drug interaction. ---
**Author:** ![drshruthi](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/drshruthi/32/4335_2.png) [@drshruthi](https://www.medboundhub.com/u/drshruthi)\ **Post date:** [May 28, 2026, 12:34pm UTC](https://www.medboundhub.com/t/must-know-deadly-drug-combination/18980/13 "2026-05-28T12:34:13Z")
Great post! Helpful in memorizing points at one place.