# Drug of the week: Aspirin/Acetylsalicylic acid **URL:** \ **Category:** MBBS\ **Tags:** dental, neetpg, mbbs, medical, pharmacy\ **Created:** [May 5, 2026, 6:25am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133 "2026-05-05T06:25:35Z")\ **Posts on this page:** 20\ **Page:** 1
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 5, 2026, 6:25am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/1 "2026-05-05T06:25:35Z")
**Aspirin/Acetylsalicylic acid** πŸ‘‰ **Class: Non-steroidal anti-inflammatory drug (NSAID)** ![image](https://canada1.discourse-cdn.com/flex033/uploads/medbound/original/2X/2/2c6166d431bce492fd18a4006b3f2e4e03bc5b45.png) πŸ‘‰ **Mechanism of action** βœ… **Non-selective, irreversible inhibitor of the Cyclooxygenase enzymes (COX-1 & COX-2)** βœ… Prevents conversion of arachidonic acid into Prostaglandins (PGs) & Thromboxane (TXA2) βœ… **↓ PGs:**** ↓ pain, fever, and inflammation** βœ… **↓ TXA2: Inhibits platelet aggregation** βš• **Therapeutic uses** βœ… **Analgesic** - For headache including mild migraine, backache, myalgia, joint pain, pulled muscle, toothache, neuralgias and dysmenorrhea βœ… **Acute Rheumatic fever** βœ… **Rheumatoid arthritis** (Anti-inflammatory dose 3-5 g/day) βœ… **Post MI & post stroke** (Anti platelet dose - 60–150 mg/day) βœ… **Prevention of Preeclampsia** βœ… **Treat Familial colonic polyposis and prevent colon cancer** βœ… **Prevents flushing upon nicotinic acid ingestion** ❌ **Adverse effects** ✨ Nausea, vomiting, epigastric distress, occult blood loss in stools ✨ **Gastric mucosal damage and peptic ulceration: MOST IMPORTANT ADVERSE EFFECT** ✨ **Hypersensitivity and idiosyncrasy** - Infrequent, includes rashes, fixed drug eruption, urticaria, rhinorrhea, angioedema, **asthma** and anaphylactoid reaction. ✨ **Salicylism** - syndrome produced by Anti-inflammatory doses (3–5 g/day); characterized by dizziness, tinnitus, vertigo, reversible impairment of hearing and vision, excitement, hyperventilation and electrolyte imbalance. ✨ **Reye’s syndrome** - Rare; causes rapid brain swelling & liver failure; affects children recovering from viral infections ✨ **Acute salicylate poisoning** - more common in children πŸ’Š πŸ§ͺ **Drug interactions of Aspirin** βœ… Warfarin/Methotrexate/Phenytoin + Aspirin -------- TOXICITY (OVERDOSE) & BLEEDING IN PATIENTS ON WARFARIN βœ… Probenecid + Aspirin --------- GOUT FLARE UP (↓ URIC ACID EXCRETION) βœ… Diuretics + Aspirin ------- FLUID RETENTION + ↓ BP CONTROL ❌ πŸ’Š **Precautions and Contraindications** ✨ **Aspirin is contraindicated in patients** with Peptic ulcer, bleeding tendencies, children suffering from viral infections & chronic liver disease. ✨ **Avoid Aspirin in** G-6PD deficient individuals, during pregnancy & lactation, diabetes, congestive heart failure & juvenile rheumatoid arthritis ✨ **Aspirin should be stopped** 1 week before elective surgery. πŸ’ŸπŸ«§ **Exam pearls** πŸ‘‰ Aspirin: Less potent & efficacious analgesic than Morphine. πŸ‘‰ Aspirin + Paracetamol/Codeine = ADDITIVE DRUG COMBINATION πŸ‘‰ Achlorhydria ↓ Aspirin absorption πŸ‘‰ Teratogenic effect of Aspirin ---- Premature closure of ductus arteriosus πŸ‘‰ Aspirin delay the initiation of labor and also prolong its duration πŸ‘‰ Ibuprofen + low dose Aspirin – Prevent COX inhibition by Aspirin β€” abolishes the antiplatelet and cardioprotective effect of Aspirin πŸ‘‰ Nimesulide β€” Choice of NSAID in patients with Aspirin induced bronchospasm MBH/PS ---
**Author:** ![Pm123](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/pm123/32/4299_2.png) [@Pm123](https://www.medboundhub.com/u/Pm123)\ **Post date:** [May 5, 2026, 6:38am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/2 "2026-05-05T06:38:02Z")
Very informative!!! Can anyone be allergic to aspirin? ---
**Author:** ![Pulipati\_Harshitha](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/pulipati_harshitha/32/4237_2.png) [@Pulipati\_Harshitha](https://www.medboundhub.com/u/Pulipati_Harshitha)\ **Post date:** [May 5, 2026, 7:23am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/3 "2026-05-05T07:23:15Z")
Veru insightful! ---
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 5, 2026, 2:17pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/4 "2026-05-05T14:17:05Z")
Thank you !!πŸ™‚ πŸ’ž ---
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 5, 2026, 2:19pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/5 "2026-05-05T14:19:52Z")
Thank you !! The prevalence of aspirin hypersensitivity reactions, including aspirin exacerbated respiratory disease (AERD), aspirin induced urticaria or angioedema, and anaphylaxis is between **0.2 to 0.9%** of the general population. ---
**Author:** ![DrPal\_28](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/drpal_28/32/4329_2.png) [@DrPal\_28](https://www.medboundhub.com/u/DrPal_28)\ **Post date:** [May 5, 2026, 2:21pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/6 "2026-05-05T14:21:06Z")
Very informative ---
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 5, 2026, 2:28pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/7 "2026-05-05T14:28:12Z")
Thank you doc ✌ πŸ™‚ ---
**Author:** ![Bansi](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/bansi/32/4324_2.png) [@Bansi](https://www.medboundhub.com/u/Bansi)\ **Post date:** [May 6, 2026, 1:14pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/8 "2026-05-06T13:14:37Z")
Informative ---
**Author:** ![DrPreya\_28](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/drpreya_28/32/4391_2.png) [@DrPreya\_28](https://www.medboundhub.com/u/DrPreya_28)\ **Post date:** [May 6, 2026, 3:39pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/10 "2026-05-06T15:39:34Z")
Very informative ---
**Author:** ![Madiha\_Khan](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/madiha_khan/32/4384_2.png) [@Madiha\_Khan](https://www.medboundhub.com/u/Madiha_Khan)\ **Post date:** [May 6, 2026, 3:43pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/11 "2026-05-06T15:43:49Z")
A Very insightful read. ---
**Author:** ![Sarahjijujacob](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/sarahjijujacob/32/4264_2.png) [@Sarahjijujacob](https://www.medboundhub.com/u/Sarahjijujacob)\ **Post date:** [May 6, 2026, 3:57pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/12 "2026-05-06T15:57:58Z")
truly mesmerizing when we read the background of its working and it being made!! ---
**Author:** ![GRL](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/grl/32/4296_2.png) [@GRL](https://www.medboundhub.com/u/GRL)\ **Post date:** [May 6, 2026, 5:33pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/13 "2026-05-06T17:33:43Z")
Informative post. Thanks for sharing πŸ˜€ ---
**Author:** ![Sakshi\_Verma](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/sakshi_verma/32/4610_2.png) [@Sakshi\_Verma](https://www.medboundhub.com/u/Sakshi_Verma)\ **Post date:** [May 6, 2026, 5:39pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/14 "2026-05-06T17:39:07Z")
Everything to know about Aspirin is here. It is going to be really helpful for exams. ---
**Author:** ![PrernaKandpal](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/prernakandpal/32/4286_2.png) [@PrernaKandpal](https://www.medboundhub.com/u/PrernaKandpal)\ **Post date:** [May 6, 2026, 5:40pm UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/15 "2026-05-06T17:40:12Z")
Thank you! This was useful for refreshing my memory. ---
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 7, 2026, 2:48am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/16 "2026-05-07T02:48:03Z")
πŸ‘βœŒGlad you found it useful ---
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 7, 2026, 3:06am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/17 "2026-05-07T03:06:11Z")
Thank you @Sakshi_Verma πŸ™‚ ---
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 7, 2026, 3:06am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/18 "2026-05-07T03:06:26Z")
Glad it helped βœŒπŸ‘ ---
**Author:** ![rahimathnisha](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/rahimathnisha/32/4301_2.png) [@rahimathnisha](https://www.medboundhub.com/u/rahimathnisha)\ **Post date:** [May 7, 2026, 4:45am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/19 "2026-05-07T04:45:56Z")
@PriyaRavichandran18 well explained πŸ‘ ---
**Author:** ![PriyaRavichandran18](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/priyaravichandran18/32/4292_2.png) [@PriyaRavichandran18](https://www.medboundhub.com/u/PriyaRavichandran18)\ **Post date:** [May 7, 2026, 4:51am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/20 "2026-05-07T04:51:10Z")
Thank you @rahimathnisha πŸ‘ ---
**Author:** ![Dawoodfayazmalik](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/dawoodfayazmalik/32/5833_2.png) [@Dawoodfayazmalik](https://www.medboundhub.com/u/Dawoodfayazmalik)\ **Post date:** [May 7, 2026, 6:00am UTC](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133/21 "2026-05-07T06:00:30Z")
Interesting [Next page](https://www.medboundhub.com/t/drug-of-the-week-aspirin-acetylsalicylic-acid/18133.md?page=2)