# Case Study: Guess the disease

**URL:** <https://www.medboundhub.com/t/case-study-guess-the-disease/3800>\
**Category:** General\
**Created:** [June 23, 2025, 3:43am UTC](https://www.medboundhub.com/t/case-study-guess-the-disease/3800 "2025-06-23T03:43:04Z")\
**Posts on this page:** 6\
**Page:** 1

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**Author:** ![kirtikaverma](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/kirtikaverma/32/395_2.png) [@kirtikaverma](https://www.medboundhub.com/u/kirtikaverma)\
**Post date:** [June 23, 2025, 3:43am UTC](https://www.medboundhub.com/t/case-study-guess-the-disease/3800/1 "2025-06-23T03:43:04Z")

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A 35 year old woman presented with fatigue, mild jaundice, and dark urine. Initially suspected as hepatitis but LFTs showed elevated alkaline phosphatase with normal ALT/AFT. Further workup revealed anti-mitochondrial antibodies.

Guess the final diagnosis.

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**Author:** ![medha](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/medha/32/476_2.png) [@medha](https://www.medboundhub.com/u/medha)\
**Post date:** [June 24, 2025, 8:24am UTC](https://www.medboundhub.com/t/case-study-guess-the-disease/3800/2 "2025-06-24T08:24:14Z")

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The fatigue dark urine and jaundice are classics of cholestatic liver disease..  
When ALT/AST is normal and alkaline phosphatase is elevated, it shows a cholestatic pattern only..  
and when AMAs are high, its autoimmune and also suggestive of Biliary cholangitis.  
Some people also develop pruritis.. and in the advanced case a liver transplant is advised.

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**Author:** ![kirtikaverma](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/kirtikaverma/32/395_2.png) [@kirtikaverma](https://www.medboundhub.com/u/kirtikaverma)\
**Post date:** [June 24, 2025, 9:26am UTC](https://www.medboundhub.com/t/case-study-guess-the-disease/3800/3 "2025-06-24T09:26:23Z")

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Cholestatic liver disease often shows up with fatigue, jaundice, and raised ALP classic yet easy to miss early on. Positive anti-mitochondrial antibodies point toward Primary Biliary Cholangitis, where early detection can delay severe outcomes like transplant.

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**Author:** ![Manisha](https://avatars.discourse-cdn.com/v4/letter/m/6f9a4e/32.png) [@Manisha](https://www.medboundhub.com/u/Manisha)\
**Post date:** [June 24, 2025, 10:27pm UTC](https://www.medboundhub.com/t/case-study-guess-the-disease/3800/4 "2025-06-24T22:27:45Z")

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Primary Biliary Cholangitis

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**Author:** ![Rutba](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/rutba/32/1473_2.png) [@Rutba](https://www.medboundhub.com/u/Rutba)\
**Post date:** [July 18, 2025, 2:34am UTC](https://www.medboundhub.com/t/case-study-guess-the-disease/3800/5 "2025-07-18T02:34:46Z")

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I guess it’s PBC

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**Author:** ![Rashichauhan](https://yyz1.discourse-cdn.com/flex033/user_avatar/www.medboundhub.com/rashichauhan/32/1301_2.png) [@Rashichauhan](https://www.medboundhub.com/u/Rashichauhan)\
**Post date:** [July 18, 2025, 7:03am UTC](https://www.medboundhub.com/t/case-study-guess-the-disease/3800/6 "2025-07-18T07:03:16Z")

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Primary Biliary Cholangitis is a chronic autoimmune liver disease that damages the small bile ducts.